Active Motif Finder (AMF) is a novel algorithmic tool, designed based on mutations in DNA sequences. Tools available at present for finding motifs are based on matching a given motif

in the query sequence. AMF describes a new algorithm that identifies the occurrences of patterns which possess all kinds of mutations like insertion, deletion and mismatch. The

algorithm is mainly based on the Alignment Score Matrix (ASM) computation by comparing input motif with full length sequence. The proposed bio-tool serves as an open resource for

analysis and useful for studying polymorphisms in DNA sequences. AMF can be searched via a user-friendly interface.